Active maturation-promoting factor is present in mature mouse oocytes

نویسندگان

  • R A Sorensen
  • M S Cyert
  • R A Pedersen
چکیده

Cytoplasmic extracts of meiotically mature mouse oocytes were injected into immature Xenopus laevis oocytes, which underwent germinal vesicle breakdown within 2 h. Germinal vesicle breakdown was not inhibited by incubation of the Xenopus oocytes in cycloheximide (20 micrograms/ml). Identically prepared extracts of meiotically immature mouse oocytes, arrested at the germinal vesicle stage by dibutyryl cyclic AMP (100 micrograms/ml), did not induce germinal vesicle breakdown in Xenopus oocytes. The results show that maturation-promoting factor activity appears during the course of oocyte maturation in the mouse.

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عنوان ژورنال:
  • The Journal of Cell Biology

دوره 100  شماره 

صفحات  -

تاریخ انتشار 1985